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Proteins Predict Significant Step Toward Development of Diabetes
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Proteins Predict Significant Step Toward Development of Diabetes

Scientists have taken an important step forward in predicting who will develop Type 1 diabetes months before symptoms appear. In a paper published online on June 29 in Cell Reports Medicine, researchers at the Department of Energy’s Pacific Northwest National Laboratory and their colleagues identify a set of altered proteins that predict a condition known as islet autoimmunity, a precursor for everyone who will ultimately develop Type 1 diabetes.

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Scientists Target Human Stomach Cells for Diabetes Therapy
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Scientists Target Human Stomach Cells for Diabetes Therapy

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

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Too Much Insulin Can Be As Dangerous As Too Little
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Too Much Insulin Can Be As Dangerous As Too Little

One hundred years of research have greatly advanced medical and biochemical understanding of how insulin works and what happens when it is lacking, but the reverse, how potentially fatal insulin hyper-responsiveness is prevented, has remained a persistent mystery. In a new study, published in the April 20, 2023 online edition of Cell Metabolism, a team of scientists at the University of California San Diego School of Medicine, with colleagues elsewhere, describe a key player in the defense mechanism that safeguards us against excessive insulin in the body.

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Study Unlocks Potential Breakthrough In Type 1 Diabetes Treatment
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Study Unlocks Potential Breakthrough In Type 1 Diabetes Treatment

For the well over 700 million people around the globe living with type 1 diabetes, getting a host immune system to tolerate the presence of implanted insulin-secreting cells could be life-changing. Rice University bioengineer Omid Veiseh and collaborators identified new biomaterial formulations that could help turn the page on type 1 diabetes treatment, opening the door to a more sustainable, long-term, self-regulating way to handle the disease. To do so, they developed a new screening technique that involves tagging each biomaterial formulation in a library of hundreds with a unique “barcode” before implanting them in live subjects.

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Different Ways to Provide Better Health Care for Diabetic Patients
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Different Ways to Provide Better Health Care for Diabetic Patients

Health care providers play a crucial role in helping their patients prevent or delay type 2 diabetes and manage all types of diabetes. The following resources can support your efforts to screen, test, and refer people to type 2 diabetes prevention and diabetes management programs and services.

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New Third Edition: The Mayo Clinic Diet
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New Third Edition: The Mayo Clinic Diet

For endocrinologists seeking methods to help patients with diabetes to lose weight, many evaluate The Mayo Clinic Diet, which is based on the concept of energy density. Jason Ewoldt, M.S., RDN, LD, with Clinical Nutrition at Mayo Clinic's campus in Rochester, Minnesota, explains, "By consuming generous amounts of low energy dense fresh or frozen vegetables and fruits, people can achieve satiety at a lower calorie intake and better manage weight. Choosing more limited amounts of healthier choices in the other food groups can improve health in addition to help manage weight."

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Can Lab-Grown Beta Cells Revolutionize Diabetes Care?
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Can Lab-Grown Beta Cells Revolutionize Diabetes Care?

Since the 1970s, clinicians have known that people with type 1 diabetes can be treated by transplanting pancreatic islets – clusters of insulin-producing “beta cells” – from a healthy organ donor. The procedure, however, is limited by a shortage of donors. The renowned diabetes researcher Douglas Melton, PhD, at Harvard University, leads a group that developed a way to increase islet supplies by generating pancreatic beta cells in the lab from stem cells. Today, researchers and scientists refine this process by coaxing stem cells to reliably develop into functional beta cells that can be transplanted into patients to produce insulin.

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